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KMID : 0352719930170010022
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Journal of Ginseng Research
1993 Volume.17 No. 1 p.22 ~ p.28
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Effect of Ginseng Total Saponin on Stress-Induced Analgesia
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김학성
정면우/장춘곤/박우규/오기완
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Abstract
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This study was undertaken to determine the effects of ginseng total saponin (GTS) on stressinduced analgesia (SIA) in mice. Intermittent foot shock (FS)-SIA was antagonized not by GTS but by naloxone in the tail flick FS-SIA which was not
antagonized by
naloxone in the T.F. test. On the other hand, GTS did not antagonize the continuous FS-SIA naloxone antagonized in the T.P. test. Also GTS antagonized psychological (PSY)-SIA which was not antagonized by naloxone in the T.F. test However, GTS did
not
antagonize the PSY-SIA which naloxone antagonized in the T.P. test. Forced swimming (FSW)-SIA was not affected by both GTS and naloxone, These results suggest that the antagonisms of intermittent FS-SIA in the T.F. test, continuous FS-SIA and
PSY-SIA by
GTS are mediated by nonopioid mechanisms but the antagonism of intermittent FS-SIA in the T.P. test by GTS is mediated by opioid mechanism.
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KEYWORD
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